Factor VIII temperature

Fig. 3.3.1. Electrical resistance as a function of temperature. Upper excipient solution lower solution with factor VIII. Cooling rate 15 °C/min. Measurements for [3.23], not published.

Fig. 3.8. Photographs taken with a cryomicro-scope of factor VIII solutions at four temperatures. At -40 °C the structure is still visible, but is more coarse compared with -44 °C. At -35 °C the structure is collapsed (Fig. 5 from [3.23]).

Some large proteins such as fibrinogen or Factor VIII can demonstrate retention by the sterilizing grade filters. The effect of solution properties such as pH, ionic strength, temperature, and operation parameters such as TMP on retention should be understood to minimize the loss of the product protein. 

Figure 2 DSC power-time scans of reconstituted Factor VIII solutions after freezedrying (a) successful product (see Figure la) and (b) failed product (see Figure lb). Crosses mark Tg and the arrows mark the temperature to which the solutions were frozen prior to the start of primary drying...

Figure 11 Plot of degradation against storage temperature for a preparation of Factor VIII. 

United States of America A.S.M.E. -Code Section VIII, Div.2 and Div. 3 American Society of Mechanical Engineers Enforced in some States Div. 2 Defined strength data as listed in this code, Safety-factors are included in the defined strength data. Div. 3 0.2%-proof stress at working temperature /1.5-2 correlated with data for... 

Isotopic enrichment has also been found by monoisotopic photosensitization for mixtures of natural mercury and alkyl chlorides and vinyl chloride by similar processes. Isotopic enrichment is dependent on such factors as lamp temperatures, flow rates, and substrate pressures. Enrichment increases with decreasing lamp temperature and increasing flow rate, since process (VIII-1) is more ellicient at low temperatures and Cl atoms react with natural mercury containing higher fractions of 202Hg in (VIII-3) at higher flow rates of HC1 or under intermittent illumination. The intermittent illumination results in higher enrichment than the steady illumination. 

For these complexes, the rate of carbonylation increases rapidly with increasing tr-alkyl character. Thus, (5-cis-butadiene)ZrCp2 (5a) is carbony-lated 2.5 times faster than the zirconocene complex of 1,2,5,6-tetramethyl-3,4-bis(methylene)tricyclo[3.1.0.0 ] hexane (51) (ambient temperature and 1 bar CO pressure) taken as a standard. Introduction of methyl groups at the internal carbon centers C2/C3 of the diene chain increases the carbonylation rate by a factor of 5 with phenyl groups at these positions increasing the rate by a factor of 250 (Table VIII). The organometallic reaction products have yet to be isolated or completely identified. Ultimately, zirconium enolate complexes (20) are probably formed in these... 

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