Ezetimibe drug interactions

A statin combined with a resin results in similar reductions in LDL cholesterol as those seen with ezetimibe. However, the magnitude of triglyceride reduction is less with a resin compared to ezetimibe, and this should be considered in patients with higher baseline triglyceride levels. In addition, gastrointestinal adverse events and potential drug interactions limit the utility of this combination. 

Reyderman L, Kosoglou T, Statkevich P, Pember L, Boutros T, Maxwell SE, Affrime M, Batra V. Assessment of a multiple-dose drug interaction between ezetimibe, a novel selective cholesterol absorption inhibitor and gemfibrozil. International J Clin Pharmacol Ther 2004 42(9) 512-8. 

Table 30.8. Drug Interactions for Ezetimibe Result of Interaction...

Kosoglou T, Statkevich P, Johnson-Levonas AO, et al. Ezetimibe a review of its metabolism, pharmacokinetics, and drug interactions. Clin Pharmacokinet 2005 44 467-494. 

Drug/Food interactions Ezetimibe may be administered with or without food. 

In a randomised, erossover study 32 otherwise healthy subjects with hy-pereholesterolaemia were given either ezetimibe 10 mg daily, fluvastatin 20 mg daily or both drugs in combination for 14 days. The combination was well tolerated, no significant pharmacokinetic interaction occurred, and an enhanced lowering of LDL-cholesterol was noted, which was considered to be clinically favourable. However, a case report describes a 52-year-old man taking fluvastatin 80 mg daily who developed elevated creatinine kinase levels 8 weeks after ezetimibe 10 mg daily was added. 

In a randomised, crossover study 18 healthy suhjeets were given either ezetimibe 10 mg daily, lovastatin 20 mg daily or both drugs in combination for 7 days. The combination was well tolerated, and no significant pharmacokinetic interaction was noted. ... 

Oswald S, Nassif A, Modess C, Keiser M, Hanke U, Engel A, Lutjohaim D, Weitschies W, Siegmund W. Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther 2010 87(6) 663-7. 

The authors of a major review of rosuvastatin concluded that its adverse reaction profile resembles that of other commonly used statins [34 ]. Increments in fiver enzymes are in most cases minor and of minimal concern, renal dysfunction is quite uncommon, myopathy is unusual, and rhab-domyolysis is rare. Interactions with other drugs are fisted but no new information given. Combinations with fenofibrate, omega-3 fatty acids, ezetimibe, rifampicin, and clopidogrel appear to be safe. 

Si NMR analysis including relaxation time measurements has been presented. Interactions between the drug and silica were investigated using ID and 2D solid-state NMR methods based on dipolar correlation using CP and spin diffusion. F solid-state NMR was used to assess drug physical state and study mobility. F- Si CP methods were used to directly detect adsorbed ezetimibe. H- C, H- F, and H- Si, and... 

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