Extracting Kinetic and Thermodynamic Properties of Local Unfolding Dynamics

2 Extracting Kinetic and Thermodynamic Properties of Local Unfolding Dynamics 

When the unfolded protic form (op) is in a steady state, (meaning [op] [cl]). 

When meaning when the rate of refolding is much faster than the rate of exchange, 

In this extreme, the rate-limiting step is a iinimolecular reaction (unfolding). This exchange mechanism, therefore, is often referred to as EXl mechanism. 

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