Extracellular matrix Enzyme detection

Hyaluronidase is involved in bacterial and fungal infections because of virulence factors evoked by tissue degradation and mediates host-pathogen interactions [47]. Since hyaluronic acid (HA) is a major component of the extracellular matrix involved in joint lubrication, a sensitive hyaluronidase assay is important. Current hyaluronidase assays rely on turbidimetric techniques that require high levels of the enz3Tne and are relatively inaccurate [47]. HA was previously shown to bind cyanines [48,49[. The detection scheme designed for CMA, CMC, and amylase enzyme described earlier was also applicable to HA and hyaluronidase activity [19]. Scaffold Destruction ... 

In a comprehensive study in which hereditary and mitochondrial diseases had been excluded, 97 out of approximately 1000 genes were detected to possess single gene mutation related to metabolic diseases [72]. When the product categories of these abnormal phenotype related genes were analyzed, the most frequently detected ones were metabolism-related enzymes, 31.2% and modulatory proteins, 13.6% and the less frequently detected ones, <10%, were receptors, transcription factors, intracellular and extracellular matrix compounds, and the others. 

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