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Toxicokinetics exposures

Current guidelines for toxicity evaluation of ophthalmic formulations involve both single and multiple applications, dependent on the proposed clinical use [39]. The multiple applications may extend over a 9-month period and incorporate evaluations of ocular irritation and toxicity, systemic toxicity, and determinations of systemic exposure (toxicokinetics). In many cases the systemic exposure from an ocular route is less than by parenteral administration, information that will assist in determining whether additional studies may be needed to establish systemic safety of the ophthalmic preparation. U.S. and international guidance documents are available [71,72], and regulations and tests have been summarized for ophthalmic preparations [39,73,74],... [Pg.427]

Concluding Remarks How Will These Data Be Used for Modeling Exposure, Toxicokinetics, and Computational Models 717... [Pg.696]

CONCLUDING REMARKS HOW WILL THESE DATA BE USED FOR MODELING EXPOSURE, TOXICOKINETICS, AND COMPUTATIONAL MODELS... [Pg.717]

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See also in sourсe #XX -- [ Pg.292 ]



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Toxicokinetic

Toxicokinetics

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