Experimental design analyte stability

The stability of the analyte from the time the sample is taken to receipt in the laboratory must be examined. Two experimental designs can be used, either a sample with a known amount or concentration is prepared or an actual sample with an unknown concentration. In either case, aliquots are taken for analysis at various times after sampling a plot of the results should show a level display if the analyte is stable or a decreasing concentration if the analyte is unstable. This should identify whether there are any problems with analyte stability if this... 

Fractional experimental designs were applied to find the most significant variables affecting the preparation of the sample in terms of the analytical performance and stability of the emulsion. 

Compared to genosensors based on GEC, the novelty of this approach is in part attributed to the simplicity of its design, combining the hybridization and the immobilization of DNA in one analytical step. The optimum time for the one-step immobilization/hybridization procedure was found to be 60 min [66]. The proposed DNA biosensor design has proven to be successful in using a simple bulk modification step, hence, overcoming the complicated pre-treatment steps associated with other DNA biosensor designs. Additionally, the use of a one-step immobilization and hybridization procedure reduces the experimental time. Stability studies conducted demonstrate the capability of the same electrode to be used for a 12-week period [66]. 

The first applications were based purely on experience from previous smaller projects. Since recently, more well-documented design criteria are available. Stability criteria for these units were determined based on analytical and experimental studies. For high energetic wave sites the units can be hydraulically anchored with cables to the sea bed. Wave transmission was studied in Canada. Technical design aspects are treated by Harris. ... 

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