Experimental Conditions and Analysis of Results

As in isocratic mode, the estimate of log P is indirect and based on the construction of a linear retention model between a retention property characteristic of the solute (logkw) and a training set with known logP ci values. To assess the most performing procedures, the three hydrophobicity indexes (( )o, CHI and logkw) were compared on the basis of the solvation equation [41]. These parameters were significantly inter-related with each other, but not identical. Each parameter was related to log P with values between 0.76 and 0.88 for the 55 tested compounds fitting quality associated with the compound nature. 

The results obtained in gradient mode by Kaliszan et al. for logkw determination are based on a relatively complex mathematical treatment, using RPLC optimization software. As described, logP values were determined in the range -2 log Port 7. The correlation coefficient between log k and log P was satisfactory, and included in the range 0.94 r 0.98. 

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