Exocrine glands muscarinic receptor agonists

Mecfianism of Action A cholinergic agonist that binds to muscarinic receptors of effector cells, thereby increasing secretion of exocrine glands, such as salivary glands. Therapeutic Effect Relieves dry mouth. 

NEUROTOXIN constituent of the fly agaric fungus Amanita muscaria and various /nocyfte spp. It is a very potent MUSCARINIC CHOLINOCEPTOR AGONIST with pronounced PARASYMPATHOMIMETIC actions. It is a HYPOTENSIVE, causes bronchoconstriction and stimulates gut, bladder and exocrine glands. Stereoisomers show only a fraction of the activity, and it is valuable as a pharmacological tool in studies on muscarinic receptors. It is very toxic orally, with stimulatory actions on the CNS (atropine sulphate may be used as an antidote). 

Interaction of cholinergic agonists with muscarinic receptors leads to well-defined pharmacological responses depending on the tissue or organ in which the receptor is located. These responses include contractions of smooth muscle, vasodilation, increased secretion from exocrine glands, miosis, and decreased heart rate and force of contraction. 

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