Excitotoxicity calcium homeostasis

Mathur C, Prasad WK, Raju VS, et al Steroids and their conjugates in the mammalian brain. Proc Natl Acad Sci USA 90 85-88, 1993 Mattes JA A pilot study of combined trazodone and tryptophan in obsessive-compulsive disorder. Int Clin Psychopharmacol 1 170-173, 1986 Mattson MP, Cheng B, Davis D, et al Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12 376-389, 1992... [Pg.692]

Excitotoxic and ischemic injury to neurons is partially mediated by dysregulation of cellular calcium homeostasis, resulting in a prolonged elevation of intracellular calcium levels. Neuronal NF-kB activation can stabilize intracellular calcium concentrations under ischemia-like conditions (Barger et al., 1995 Barger and Mattson,... [Pg.306]

Cheng B, Chiistakos S, Mattson MP (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neui on 12 139—153. [Pg.355]

Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. 1992. /3-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12 379-89... [Pg.579]

A key feature of excitotoxic cell death involves an imbalance in Ca " homeostasis and demonstration of the activation of L-type voltage-sensitive calcium channels (VSCCs) allowing entry of Ca " that is localized to vulnerable brain regions (Hazell et al. 1998) (Figure 32.3). Along with the rise in... [Pg.575]

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