Excess maternal iodine exposure

Developmental Toxic Effects of Excess Maternal Iodine Exposure... 

Therefore, based on the above Hmited evidence, we conclude that excess iodine exposure may influence maternal-fetal TH metabohsm by three mechanisms (1) excess iodine affects the maternal hormone thyroid level by inhibition of thyroid function and/or Dl activity (2) excess iodine has an effect on maternal—fetal TH transfer by affecting placental D2 and D3 activity and (3) excess iodine transferred by the placenta has a direct inhibition on the development and function of the fetal thyroid gland (Figure 88.2). 

Excess iodine exposure during pregnancy may influence maternal-fetal TH metabolism and result in fetal/neo-natal hypothyroidism or hyperthyroidism therefore,... 

Mice seem to be more susceptible to the toxicity of excess iodine. Gao et al. (1998) reported that a decrease in average body length and abnormal fusion of the supra-occipital were observed in fetuses from maternal mice exposed to 3.0mg/l iodine for 3 months. Li et al. (2001) also reported that maternal exposure to 3.0mg/l iodine had an adverse effect on pregnancy and embryonic development in mice, resulting in an increased incidence of abnormal fetuses and skeletal malformation. However,... 

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