Examples of Stabilizing PLGA-Encapsulated Proteins

The deleterious effect of ubiquitous PLGA acidity on encapsulated peptides has been understood for many years (38). As 

Stabilization of BSA in PLGA Microspheres by Adding Insoluble Base 

The stabilization effect of insoluble base on protein in PLGA microspheres has also been demonstrated (8), as shown in Table 4. BSA also was shown to form non-covalent aggregates ( 25-70%) when encapsulated in w/o/w PLGA microspheres, confirming that an acidic microclimate also commonly develops in PLGA 50/50 microspheres (41,43). Whereas the BSA 

51 days with 94% recovery. This preparation controlled the release of BSA slowly and continuously over the entire experiment after a 32% hxu st (data not shown). 

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