EVOP Analysis of an Organic Synthesis

We consider the case of a discontinuous organic synthesis, which occurs in a liquid medium undergoing intensive agitation the temperature is controlled by an external heating device. The process efficiency is characterized by the conversion defined here as the ratio between the quantity of the useful species obtained and the theoretical quantity of the same species. This last value is fixed by the thermo- 

We assume that the standard temperature and reaction time are fixed to 85 °C and 180 min. but small changes ( 5 °C and 10 min) have been observed to affect the process efficiency. However, these variations do not affect the process drastically. Moreover, to begin the analysis we can observe a similitude between this concrete case and the example shown in Fig. 5.12. Indeed, the working plan is a CFE 2 which is noted as 1 2 3H 5 in Fig. 5.12. The superscript indicates that we are in the first phase of the EVOP procedure. The dimensionless coordinates for each point of the CFE22 plan are 1 (0,0), 2 (-l,l), 3 (1,1), 4 (1,-1), 5 (-l,-l). 

We can identify the first coordinate of 1 to 5 point of the CFE 2 plan which is Xj = (t - 85)/5 and the second point coordinate is X2 = (t - 180)/10. Table 5.36 contains the results for the first four cycles of the first phase of the particular EVOP method. 

If we consider the coordinates of the points of the CFE plan, we observe that points 3 and 4 are the maximum values of Xj, whereas points 3 and 5 have the maximum values for X2- Consequently, the effects of the factors and of their interactions will be written as follows  

We frequently use the concepts of mean values and variances in the application of the EVOP method. Before sho-wing the concrete computations of this actual application, we need to recall here the expression for the confidence interval of a mean value p = x t(,s/- /n where s is the variance, x is the mean value of the selection, n gives the selection dimension and t(, is the value of the Student random variable with a significance level equal to a and with v = n -1 degrees of freedom. Table 5.37 shows the EVOP evolution from one cycle to another respect to the data given in Table 5.36. The computations from Table 5.37 show that  

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