Euphorbia jolkini

In the continuing search for irritant substances from Euphorbia species, two unusual epoxides, jolkinolides A and B [(30) and (31) respectively], have been isolated from Euphorbia jolkini. Hydrogenation of jolkinolide B gave a diol (32) which was converted via the phenolic acid (33) into ferruginol. 

Isobomeol demonstrated potent anti-Tierpes simplex virus-1 (anti-HSV-1) activity by inhibition of virus replication and the glycosylation of viral proteins. As a result, HSV-1 loses its infectivity [36]. Monoterpene derivatives cineol and bomeol have also been shown to be potent anti-HSV-1 agents. It has been shown that putranjivain A, isolated from Euphorbia jolkini Euphorbiaceae), may affect late stages of HSV-2 replication by inhibiting viral attachment and cell penetration... 

Lathyranes are, for the most part, isolated from Euphorbiaeeae. Representatives include 7p-hydroxylathyrol from Euphorbia lathyris, the cinnamic acid esters denoted as joUcinols from E. jolkini, and ingol, a skin-irritating and antineoplastic hydrolyzate obtained from E. ingens and E. kamerunica. 

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