Eucomic acid

An attempt to determine the absolute stereochemistry of natural eucomol (10) by chemical degradation to a product of known chirality led to a series of new transformations (64). It was anticipated that reduction of (10) to the deoxo derivative (58) followed by oxidative cleavage of ring A would lead to the lactone (59). From this intermediate the key compound (61) should be obtained by subsequent reduction. The derivative (61) is easily prepared from eucomic acid (60) whose absolute stereochemistry has been elucidated recently (34, 36). 

Erythropentulose, Cl Erythrose, Cl Erythroxydiol Y, T34 Erythrulose, C2 Eserine, K30 Ethambutol, A8 Ethanoanthracenes, X4-5 7-ethylideneglutamic acid, AlO 5j3-etianic acid, T49 Eucomic acid, A29 Eucommiol, A25 ... 

Nakazato et al. (284) determined the CF and geniposidic acid content in leaves of Eucom-mia ulmoides used in health foods and beverages. The samples (dried leaves or granules) were refluxed with water, filtered, acidified, and cleaned up on aMegaBondElut Cl8 cartridge linked to an Elut SAX cartridge. The eluate (with MeOH-Tris hydrochloride buffer) was applied to a Inertsil ODS-2 column at 40°C and eluted with an ACN-phosphate solution mixture. Detection was performed at 240 nm, reaching a DL of 10 fig/g. 

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