Ethylsuccinate syrup

Optimal treatment of chlamydial ophthalmia neonatorum has not been determined. The CDC recommends erythromycin base or ethylsuccinate syrup 50 mgAg/day orally divided into four doses daily for 14 days. Topical antibiotic therapy alone is inadequate and unnecessary when systemic treatment is administered. Another important aspect of treatment is concurrent therapy for the mother and her sexual partners. 

FIGURE 2.2 An example of fine-tuning of pharmacologically active chemicals Erythromycin 2 -ethylsuccinate and clarithromycin are semisynthetic derivatives of the macroUde antiinfective erythromycin. The small molecular change in the former leads to the elimination of bitterness which is important as this class of drugs is often used in pediatrics and administered as a syrup. In the latter, because hemiketal formation is no longer possible (arrow), clarithromycin is stable in the acidic milieu of the stomach (pH 2). 

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See also in sourсe #XX -- [ ]

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