Ethylenediamine hydrate

A mixture of 198 g (1 mol) theophylline and 60-78 g (0.75-1 mol) ethylenediamine hydrate in 300 g of water was stirred at 50°C and then the mixture was concentrated in vacuo. The product (aminophylline) was separeted by suction filtration. Aminophylline was used as an aqueous solution. 

Already in the early experiments involving treatment of iron tetracarbonyl with ethylenediamine hydrate, we observed that upon acidification of the solutions an extraordinarily intense repugnant smell was released (3). I can still clearly remember the day when I, together with my co-workers Leutert and Vetter, at the Heidelberg Institute, was able to freeze out a volatile water-clear liquid from the decomposition of the ethylenediamine-... 

Use. Ethylenediamine hydrate is used in the manufacture of aminophylline and in the preparation of aminophylline injections. 

Since anhydrous ethylenediamine attacks cork and rubber stoppers, ground glass equipment must be used. Five hundred grams of NaOH and 875 ml. of commercial ethylenediamine hydrate are heated overnight on a steam bath. Two layers form the upper layer is decanted, treated with additional 150 g. of NaOH for several hours the supernatant is decanted again and distilled. B.p. 116-117°C at 760 mm. Yield almost quantitative. (Propylene-diamine can be dehydrated in the same manner.)... 

Similarly, the corresponding carbonatoethylenediamine complexes have been synthesized Originally solid material prepared by saturating ethylenediamine hydrate with carbon dioxide was used in order to realize a mild substitution at the first-step, but we now recommend ethylenediamine instead of such salt-like material, because of convenience in procedure and a good yield of K[Co(C03)2en] H20. Other familiar complexes, [CoC03(en)2]X and [Co(en)3]X3, are also accessible. 

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