Ethylene derivatives enamines, synthesis

Via intermediates Synthesis of ethylene derivs. from enamines via thioenolethers a,y - thylene-y-lactone side-chain synthesis... 

Finally, a primary amine directed enamine activation has been used for a highly enantioselective conjugate addition of cyclohexanones to l,l-bis(benzenesulfonyl) ethylene [144], The reaction, which is efficiently catalyzed by Cinchonidine-derived primary amine 100 (10-20 mol%) is carried out in CHCI3 at 0°C in the presence of benzoic acid as cocatalyst. As depicted in Scheme 2.46, an enantioselective synthesis of (5,5)-sodium cyclamate has been achieved following this methodology. 

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