Ethyl reaction with amines

Rhenium(V) 4-tolylimido complexes with the hydrotris(pyrazolyl)borate ligand, HB(pz)3, are formed on heating the 0x0 derivatives [ReOX2 HB(pz)3 ] (X = Cl, I) with 4-toluidine, whereas reactions with amines at ambient temperatures only give 0x0 complexes of the composition [ReO(NHR)Cl HB(pz)3 ]. The [Re(NC6H4-4-Me)X2 HB(pz)3] complexes react with ZnEt2 with formation of imido-ethyl complexes of the composition [Re(NC6H4-4-Me)Cl(Et) HB(pz)3 ]. " ... 

Reaction of ethyl chloroformate with amines to give ethyl alkylcarba-mates [28]. 

In the displacement reaction with sodium ethoxide, the 4-chloro group in ethyl 4-chloro-6-flu-oro-7-(4-tolylsulfanyl)pyrido[2,3-r]pyridazine-3-carboxylatc (2) shows the higher reactivity compared to the fluorine in the 6-position (compare also the reaction with amines below), although the 4-ethoxy compound 5 is obtained in only 30% yield.9... 

The reaction of ethyl 3-isothiocyanatopyridine-2-carboxylate with ethanol at reflux temperature results in the formation of the corresponding thiourethane which, by reaction with amines in anhydrous ethanol, can be converted into pyrido[3,2-c/]pyrimidin-4(3//)-one derivatives, partly with subsequent substitution of the sulfanyl group.428... 

The reaction between (2-oxoalkyl)phosphonic diesters and triethyl orthoformate in the presence of ironflll) chloride yields the enol ethyl ethers", while reactions with amines afford enamines. When heated with P4O10, enols may undergo dehydration, as in the reaction with diphenacylphosphinic acid in hot toluene, which gives the 1,4-oxaphospho-rin333". ... 

The reactivity of the ethenediazonium salt 9.100 towards the nucleophiles mentioned shows that it has the properties of the corresponding carbocation, since it can ethylate the nucleophile and is prone to attack at the C()ff)-atom of the original ethene-l-diazonium ion. The thermal decomposition pattern is typical of that for an oxonium salt. Reactions with amines are similar to those of ketene acetals. No product that could be explained in terms of an azo coupling reaction, e.g., with 2-naphthol, could be observed. The electrophilicity of the diazonio group is, therefore, low. N-Azo coupling products with azide ions have been postulated with good arguments, however, by Kirmse and Schnurr (1977) with certain short-lived ethene diazonium intermediates produced from nitroso oxazolidones. 

Reaction with ammonia and amines (Sec tion 20 12) Esters react with ammonia and amines to form amides Methyl and ethyl esters are the most reactive... 

Reaction of ethyl chloride with an alcohoHc solution of ammonia yields ethylamine, diethylamine, triethylamine, and tetraethyl ammonium chloride (10,11) (see Amines, lower aliphatic). 

At higher temperatures the mixture of 10 and methyl vinyl ketone yields the 1,4-carbocyclic compound as described previously. Methyl isopropenyl ketone (5), ethyl acetylacrylate (d), 2-cyclohexenone (21), and 1-acetyl-1-cyclohexene (22) also undergo this type of cyclization reaction with enamines at higher temperatures. This cycloalkylation reaction occurs with enamines made of strongly basic amines such as pyrrolidine, but the less reactive morpholine enamine combines with methyl vinyl ketone to give only a simple alkylated product (7). Chlorovinyl ketones yield pyrans when allowed to react with the enamines of either alicyclic ketones or aldehydes (23). 

Bromination of the methyl group of (249) with A -bromosuccinimide, followed by reaction with excess secondary amine gave (250) which shows combined analgesic and antitussive properties. The Reformatsky reaction has also been used for the preparation of 2-amino-ethyl 3,3-diaryl-3-hydroxypropanates (251) as well as their dehydration products. The propene amides (252) have also been prepared for pharmacological evaluation. In l-methyl-3-bis (2-thienyl)-... 

Reaction of 9,10-difluoro-7-oxo-2,3-dihydro-7//-pyrido[l, 2,3- e]-1,4-ben-zothiazine-6-carboxylic acid and its ethyl ester with B(OH)3 in AC2O in the presence of ZnCl2 afforded 6-[(diacetoxyboryl)oxycarbonyl] derivative 323 (R = OAc)], which was reacted with primary and cyclic amines to give 10-amino-9-fluoro-7-carboxylic acid derivatives 324 (97MI41, 98MI30). 6-[(Difluoroboryl)oxycarbonyl derivative 323 (R = F) was obtained from ethyl 9,10-difluoro-7-oxo-2,3-dihydro-7//-pyrido[l,2,3- fe]-l,4-benzothiazine-6-carboxylate with BF3-THF complex. Reaction of 323 (R = F) and 1-methylpiperazine in DMF at 50-60 °C and subsequent acidic hydrolysis afforded 7 (97MI1). 

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