Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

2 -0- ethyl-modified ribose

Isis, in collaboration with Genzyme, is developing a cholesterol-lowering drug, mipomersen, which is a secrmd generation 2 -G-(2-methoxy) ethyl-modified ribose ON. Unlike conventional therapies, mipomersen acts directly on apoUpoprotein BlOO, instead of inhibiting HMG-CoA reductase (as does Lipitor). Recent data showed that the drug is able to dramatically reduce low density lipoprotein (LDL) levels but also caused an unexpected increase in liver enzyme levels above the... [Pg.167]

See other pages where 2 -0- ethyl-modified ribose is mentioned: [Pg.451]    [Pg.530]    [Pg.108]    [Pg.141]    [Pg.712]    [Pg.141]    [Pg.370]    [Pg.184]    [Pg.259]    [Pg.192]    [Pg.8]    [Pg.157]   


SEARCH



© 2024 chempedia.info