Ethyl 2-methylthiazole-4-carboxylate

On the other hand, treatment of ethyl a-chloroacetylacetone with 157, Rj = NH4, furnished a product (m.p. 175°C) in very good yield, whose properties agree with the structure of ethyl-2-hydroxy-4-methylthiazole-5-carboxylate (158), Ri=H, R2 = Me, R3 = C02Et) (Scheme 81) (221). 

In case of reaction of ethyl 2-bromo-4-methylthiazole-5-carboxylates with potassium fluoride the substitution was facilitated by crown ether [84],... 

Ethyl acetoacetate has been thiocyanated, but the primary Jhio-cyano derivative has not been isolated owing to hydrolysis to ethyl 2-hydroxy-4-methylthiazole-5-carboxylate (19% yield). ... 

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