Ethyl ethylcyanoacetate

Ethyl ethylcyanoacetate, 26, 33 Ethyl ethylidene-frw-acetoacetate, 27,24 Ethyl (1-ethylpropenYl)-methyl-cyanoacetate, 25, 44 Ethyl (1-ethylpropylidene)-cyano-acetate, 26,46 Ethyl formate, 3A, 12 26, 29 Ethtyl 1,16-hexadecanedicarboxyl-ate, 21, 48... 

Ethyl ethylcyanoacetate and ethyl propylcyanoacetate have been prepared by the same method in pelds of 85 and 94%, respectively. Other aldehydes and ketones have been used under slightly different conditions to prepare other ethyl monoalkyl-cyanoacetates. ... 

Ethylcyanoacetate (227), Rj = CH2C02Et, also reacts with ethylthio-glycolate to afford the corresponding ethyl-2-thiazolylacetate (230), R, -CH2C02Et, R2 = H, after cyclization of the acyclic intennediate in the presence of sodium acetate (542). 

In its manufacture, methyl ethyl ketone is condensed with ethylcyanoacetate to give ethyl-2-cyano-3-methyl-2-pentenoate. That, in turn, adds HCN to give ethyl-2,3-dicyano-3-methyl-pentanoate. Saponification and decarboxylation gives 2-methyl-2-ethyl succinonitrile. Heating with aqueous NH3 gives the diamide which loses NHj and cyclizes to ethosuximide. 

Rh(PNBD)- NH2-MCM41 Benzaldehyde + ethylcyanoacetate Ethyl 2-cyano-3-phenylpropionate Base + hydrogenation (85)c — 1 h under Ar + 12 h under H2 (7 bar) [4]... 

Hydroxythiazole, from chloroacetaldehyde and ammonium thiocaibamate, 258 4-Hydroxy-2-thiazolecarboxylic acid ethyl ester, self condensation of, 294 synthesis of, from ethylcyanoacetate and ethylthioglycolate, 294 from thioamides and a-haloacids or esters, 294... 

While oxiranes afford with sodium ethylcyanoacetate only oc-cyano-y-butyrolactone, i.e., the insertion of the hydroxyethyl moiety into ethyl cyanoacetate,6 thiiranes give with sodium cyanoacetate, in a one-step... 

The catalytic performance of the NCNT was tested via the Knoevenagel condensation of benzaldehyde (BA) with ethylcyanoacetate (ECA) to form ethyl-a-cyanocinnamate (ECC). The NCNT (1 g) were crushed, heated to 423 K under vacuum and maintained under these conditions for 1 h. The reactants, BA (0.01 mol) and ECA (0.01 mol), were dissolved in ethanol (50 mL) and carbondioxide was removed using the freeze-thaw method. The solution was then added to the NCNT and the reaction was performed under reflux conditions. To monitor the progress of the reaction, samples of the reaction mixture were taken regularly for GC analysis. 

In the following year (2012), Rao Kolia and Lee extended the reaction for the synthesis of such biologically relevant 2-amino-4//-chromen-4-ylphosphonate derivatives (35) from the one-pot three-component condensation of substituted salicylaldehydes, malononitrile (or ethylcyanoacetate) and triethylphosphite in the presence of ethyle-nediamine diacetate (EDDA) as a catalyst in alcohol under room temperature conditions (Scheme 15). Recently, Brahmachari and Laskar (2014) have also developed an energy-efficient multicomponent one-pot procedure for the facile synthesis of a wide range of diverse (2-amino-3-cyano-4/f-chromen-4-yl)phosphonic acid diethyl esters at room temperature from the reaction of salicylaldehydes, malononitrile (or ethyl cyanoacetate) and triethylphosphite on the surface of a reusable heterogeneous MgO-nanocatalyst in aqueous ethanolic... 

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