Ethyl 4 -chlorophenoxyisobutyrate

Synonyms. Ethyl Chlorophenoxyisobutyrate Ethyl Clofibrate. Proprietary Names. Amotril Atheropront Atromidin Atromid-S Azionyl Claripex Clofibral Clofirem Lipavlon Liprin(al) Normolipol Novofibrate Regelan Skleromexe. 

Atromld S (CPIB, ethyl chlorophenoxyisobutyrate) has now been released for sale in the U.S.A. Reports of its effectiveness in lowering serum triglycerides and senrni cholesterol continue to appear. It has shown effectiveness in the diabetic with concomitant disappearance of retinal... 

Thorp JM, Waring WS. Modification and distribution of lipids by ethyl chlorophenoxyisobutyrate. Nature 1962 194 948-949. 

Green, K. G., W. H. W. Inman, and J. M. Thorp Multicentre trial in the United Kingdom and Ireland of a mixture of ethyl chlorophenoxyisobutyrate and androsterone (Atromid). A preliminary report. J. Atheroscler. Res. 3, 593 (1963). 

JuRAND, J., and M. F. Oliver The effects of ethyl chlorophenoxyisobutyrate on serum cholesteryl, triglyceride and phospholipid fatty acids. J. Atheroscler. Res. 3, 547 (1963). 

A comparison of the effects of ethyl chlorophenoxyisobutyrate and nicotinic acid on... 

S. D. Roberts, T>. Hayes, J. F. Pantridge, M. M. Sttzman, and I. Bersohn Effect of Atromid and ethyl chlorophenoxyisobutyrate on anticoagulant requirements. Lancet 1963/1,143. 

The ethyl p-chlorophenoxyisobutyrate may be obtained by heating a mixture of 206 parts of dry p-chlorophenoxyisobutyric acid, 1,000 parts of ethanol and 40 parts of concentrated sulfuric acid under reflux during 5 hours. The aicohol is then distilled off and the residue is diluted with water and extracted with chioroform. The chloroform extract is washed with sodium hydrogen carbonate solution, dried over sodium sulfate and the chloroform removed by distillation. The residue is distilled under reduced pressure and there is obtained ethyl p-chlorophenoxyisobutyrate, BP 148° to 150°C/20 mm. 

Chemical Name 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester Common Name Ethyl p-chlorophenoxyisobutyrate Structural Formula ... 

Reddy, J. K., and Qureshi, S. A. (1979). Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) in rats. Br J Cancer 40, 476-482. 

Clofibrate, the prototype of the fibric-acid derivatives, is the ethyl ester of p-chlorophenoxyisobutyrate. Gemfibrozil is a nonhalogenated phenoxypentanoic acid and thus is distinct from the halo-generated number of fibric-acid analogs (e.g., fenofibrate, bezafibrate, and ciprofibrate have been developed and are used). 

Malhotra, S.C., and M.M. Ahuja. 1971. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction A, ethyl-p-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J. Med. Res. 59(10) 1621-1632. 

Kritchevsky, D., Sallata, R, and Tepper, S.A. (1968) Influence of Ethyl p-Chlorophenoxyisobutyrate (CPIB) upon Establishment and Progression of Experimental Atherosclerosis in Rabbits, J. Atheroscler. Res. 8,755-761. 

It has recently been reported (1) that administration of the hypolipidemic drug clofibrate (ethyl-a-p-chlorophenoxyisobutyrate) to rats is followed by a great increase of the CoA-pool in their liver. The increase may amount to about 3-fold, and is mainly due to an increase of free CoA (1,2). 

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