Ethionamide and protionamide

Ethionamide and protionamide have often proved to be effective in non-tuberculous mycobacterial infections. Acute rheumatic symptoms and difficulty in the management of diabetes have been reported (1). 

Mental depression, weakness, drowsiness, and hjrpoten-sion are not rare in patients taking ethionamide or protionamide (1,2). Other neurological reactions include diplopia, olfactory disturbances, metallic taste, dizziness, paresthesia, headache, and tremor (3). 

Ethionamide is teratogenic (15,16), and neither ethionamide nor protionamide should be administered during the first trimester of pregnancy. 

Jaundice, liver damage and deaths have occurred in other leprosy patients given rifampicin and protionamide or ethionamide. Protionamide does not affect the pharmacokinetics of either dapsone or rifampicin. ... 

Nausea, vomiting, and anorexia reflect gastric intolerance, and ethionamide is best taken with meals (1,2). Protionamide has better gastric tolerance, but patients with a history of stomach ulcer are susceptible to gastric problems (11). 

Antimycobacterials and related drugs Aminosalicylic acid (PAS), Capreomycin, Clofazimine, Cycloserine, Dapsone, Ethambutol, Ethionamide, Isoniazid, Methaniazide, Protionamide, Pyrazinamide, Rifabutin, Rifampicin (Rifampin), Rifamycin, Rihipentine, Rihiximin... 

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