Ethical issues rationing

Biosimulation holds great promise for the future in solving key ethical issues relating to drug development and drug use. Biosimulation allows for a better planning of experiments, a more rational exploitation of the information acquired in each test, and a better prediction of the effect of new medicines before administering them in animals and humans and may contribute to ... 

The ethics course initially was designed for a 14-week academic semester with the goal of situating key ethical issues related to computing and information ethics in an international context. Lectures in the first half of the semester (weeks 1 to 6) are related to moral values and a variety of ethical theories in particular, traditional Western ethics (Kantianism, social contract, utilitarianism, and virtue ethics), non-traditional Western ethics (rational egoism, ethics of care, and situated knowledge), and non-Western ethics (Classical Chinese ethics, Indian ethics, Buddhist ethics, Islamic ethics, and Ubuntu culture). In the second half of the semester (weeks 8 to 14) lectures discuss ethical issues related to information technology. 

In in vivo studies, an important issue is the quality of ECG recordings and the methods used for the analysis. A few years ago, a survey reported on the practice in the pharmaceutical industry to assess the potential for QT prolongation and concluded that the majority view in the industry is not necessarily best practice [153]. After this publication, a lot of work has been done to improve the performance of in vivo models, although it should be acknowledged that their cost (together with some ethical considerations on the rational use of animals) makes them unsuitable for large-scale screening. 

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