Ethanol acute rise

In order to overcome the inherent problem associated with pulmonary aqueous solution and dry powder aerosols, Choi et al. [2] developed an ethanol suspension of insulin for inhalation, in which the solid insulin is suspended in ethanol and aerosolized with a commercial compressor nebulizer. The aerosol insulin particles were found to be 1.5 pm, with a geometric standard deviation of 1.3 pm. Exposure of rats to 10 mg/mL insulin aerosol resulted in a drastic fall in blood glucose and a marked rise in serum insulin level. The bioavailability of insulin/ethanol aerosol was 33% relative to SC injection, and comparable to that of insulin aerosols in aqueous solution and dry powder form. No acute toxic effects were detected in the rat lungs or airways [2]. 

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