Ethanol absorption

In a less polar solvent, 951 ethanol, absorptions at 241 and 286 nm were reported with the A - B transition being obscured by solvent absorption. Also in HFIP, DMT displays a fluorescence approximately 100 times as intense as in ethanol solution was reported. 

Ethanol absorption Pleasant effects of fermented grain likely to have encouraged cereal agriculture-bas ed civilization 13.7D... 

Costunolide Laurus nobilis (bay leaf, laurel) Ethanol absorption inhibited... 

Reynosin Chrysanthemum parthenium Ethanol absorption inhibited... 

Ethanol absorption is influenced by food intake (which restricts the rate of absorption) the higher the dietary fat content, the slower the time of passage and the longer the process of absorption. First-pass metabolism in the stomach is important. Women absorb and metabolise alcohol differently from men their lower body water content and a lower activity of alcohol dehydrogenase (ADH) in the stomach result in a more rapid and significant absorption. 

Fraser AG, Hudson M, Sawyer AM et al. Ranitidine has no effect on postbreakfast ethanol absorption. Am J Gastroenterol 1993 88 217-21. 

Gibbons DO, Lant AF. Effects of intravenous and oral propantheline and metoclopramide on ethanol absorption. Clin Pharmacol Ther 1975 17(5) 578-84. 

What is the molecular weight or other drug molecule-specific dependence on ethanol absorption ... 

Chlorophyll c. Structure Dougherty et al.. J. Am. Chem. Soc. 88, 5037 (1966). Reddish-black hexagonal bipyramids or four-sided plates from dil ethanol. Absorption max (acetone) 628, 580, 442 nm (E t 15.8, 10.7, 115.9). Sol in methanol, ethanol, ethyl acetate practically insol in ether, acetone. 

Clusters of brick-red needles from ethanol. Absorption max (ethanol) 217, 230, 440 nm (log t 4.46, 4.22, 3.47). Sol in water, methanol, ethanol (amorphous coprogen only), propanol, benzyl alcohol, Celiosolves practically insol in ether, ethyl acetate, chloroform, benzene, Cellosolve esters. 

Example 4.6 Design of a Sieve-Tray Column for Ethanol Absorption... 

Camellia japonica used in traditional Chinese and Japanese (Kampo) healing for treatment of hematemasis, and to prevent or lessen alcohol intoxication during heavy drinking. single low-dose oral administration caused inhibitory effect on ethanol absorption... 

Aralia elata used in traditional Chinese treatments to prevent or lessen ethanol intoxication. active ingredient inhibiting ethanol absorption identified as the elatoside oleanolic acid oligoglycoside. likely mechanism involves inhibition of EtOH absorption across cell membranes in digestive tract. 

Fig. 10. Electronic absorption dashed line) and emission continuous line) spectrum of [(bipy)Pt(tdt)] in ethanol. Absorption 4.9 x mol L at r.t., 1-cm cell. Emission at 77 K, Aexc = 546 nm intensity in arbitrary units...

Chemically, domoic acid is (25,35,45)-2-carboxy-4-l-methyl-5(R)-carboxyl-l(Z)-3( )-hexadi-enyl pyrrolidine-3-acetic acid (C15H21NO6) and has an anhydrous molecular weight of 311.14, a melting point of 215-216°C (dihydrate), and a UV (ethanol) absorption spectrum with a maximum of 242 nm, although this is pH dependent. Structurally, domoic acid is very similar to another known toxin, kainic acid, and both are analogues of the amino acids glutamate and proline. The structures of domoic and kainic acid are shown in Figure 20.1. 

It was found that the 3-0-glucuronide moiety and the 28-carboxyl group in oleanolic acid glucuronide saponin were required to exert the inhibitory activity. Elatoside A and B were found to show potent inhibitory activity on ethanol absorption. 

Yoshikawa, M., T. Murakami, H. Matsuda, et al. 1996. Bioactive saponins and glycosides. II. Senegae Radix. 2) Chemical stmc-tures, hypoglycemic activity, and ethanol absorption-inhibitory effect of E-senegasaponin c, Z-senegasaponin c, and Z-senegins II, III, and IV. Chem. Pharm. Bull. 44(7) 1305-1313. 

Yoshikawa, M., T. Murakami, T. Ueno, et al. 1995. E-Senegasaponins A and B, Z-senegasaponins A and B, Z-senegins II and III, new type inhibitors of ethanol absorption in rats from Senegae Radix, the roots of Polygala senega L. var. latifolia Torrey et Gray. Chem. Pharm. Bull. 43(2) 350-352. 

Although others, including Joseph von Mering, proved this to be the case, it was not until the 1960s that evidence was provided that ethanol absorption depends only upon its concentration in gastric contents and is independent of their acidity. 

FIGURE 16.11 Densification of two cubic-shaped sponges into small pellets (a flat carpet and a spherical particle, respectively) and fidl recovery to original structure upon ethanol absorption. 

A key feature and important advantage of this method is a possibility to synthesize the asymmetric representatives of BODIPY (hitherto almost unknown) due to the involvement of a-unsubstituted pyrroles (having other substituents in other positions of the pyrrole ring) in condensation with 2,2,2-trifluoro-l-(pyrrol-2-yl)-l-ethanols. Absorption and emission bands of such fluorophores are red shifted (600-670 nm), the fluorescence quantum yield being close to 1.0 [642],... 

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