Estrogen therapy migraine with

Exacerbations of other conditions Endometriosis may be exacerbated with administration of estrogen therapy. Estrogen therapy also may cause an exacerbation of asthma, diabetes mellitus, epilepsy, migraine, or porphyria use with caution in patients with these conditions. 

Nausea and breast tenderness are common and can be minimized by using the smallest effective dose of estrogen. Hyperpigmentation also occurs. Estrogen therapy is associated with an increase in frequency of migraine headaches as well as cholestasis, gallbladder disease, and hypertension. 

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