Estrogen heterodimeric

OGAWA S, INOUE S, WATANABE T, HIROI H, ORIMO A, HOSOI T, OUCHI Y, MURAMATSU M (1998) The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun. 234 122-6. 

Hussey SL, Muddana SS, Peterson BR. Synthesis of a beta-estradiol-biotin chimera that potently heterodimerizes estrogen receptor and streptavidin proteins in a yeast three-hybrid system. J. Am. Chem. Soc. 2003 125 3692-3693. 

Tremblay, G.B., Tremblay, A., Labrie, F. and Giguere, V. (1999) Dominant Activity of activation function 1 (AF-1) and differential stoichiometric requirements for AF-1 and -2 in the estrogen receptor a-p heterodimeric complex. Molecular and Cellular Biology, 19, 1919-1927. 

A FIGURE 11-42 Consensus sequences of DNA response elements that bind three nuclear receptors. The response elements for the glucocorticoid receptor (GRE) and estrogen receptor (ERE) contain inverted repeats that bind these homodimeric proteins. The response elements for heterodimeric receptors contain a common direct repeat separated by three to five base pairs, for the vitamin D3 receptor (VDRE), thyroid hormone receptor (TRE), and retinoic acid receptor (RARE). The repeat sequences are indicated by red arrows. [See K. Umesono etal., 1991, Ce//65 1255, and A. M. Naaretal., 1991, Ce//65 1267]... 

S.S. Muddana, B.R. Peterson, Facile synthesis of cids biotinylated estrone oximes efficiently heterodimerize estrogen receptor and streptavidin proteins in yeast three hybrid systems, Org. Lett. 2004, 6, 1409-1412. 

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