Esomeprazole adverse effects

MOCLOBEMIDE PROTON PUMP INHIBITORS -OMEPRAZOLE/ ESOMEPRAZOLE Possible t efficacy and adverse effects of modobemide Inhibition of CYP2C19 Monitor more closely effect only seen in extensive CYP2C19 metabolizers. Dose i may be required... 

BZDs PROTON PUMP INHIBITORS -OMEPRAZOLE/ ESOMEPRAZOLE T efficacy and adverse effects, e.g. prolonged sedation Inhibition of metabolism via CYP4S0 (some show competitive inhibition via CYP2C19) Monitor for t side-effects, and 1 dose as necessaiy. Likely to delay recovery after procedures for which BZDs have been used. Consider alternative proton pump inhibitor, e.g. lansoprazole or pantoprazole... 

Esomeprazole is the 5-isomer of omeprazole. The pharmacology, pharmacokinetics, efficacy, and safety of esomeprazole have been reviewed (1). Esomeprazole produces acid control comparable to that of currently available proton pump inhibitors. It undergoes less hepatic metabolism than omeprazole, has an oral availability of 89% at a dose of 40 mg, and a half-life of 1.5 hours. Esomeprazole is well tolerated its common adverse effects are diarrhea, headache, nausea, abdominal pain, respiratory infection, and sinusitis. 

To assess symptom control, esomeprazole 20 mg on demand has been compared with placebo on demand (maximum of one dose a day) for 6 months in a multicenter, double-blind study in 342 endoscopy-negative patients with gastro-esophageal reflux disease (2). There was complete resolution of heartburn after 4 weeks of daily esomeprazole therapy. On-demand therapy with esomeprazole was significantly more effective than placebo in controlling symptoms. The frequencies of adverse effects and laboratory profiles were similar in the two groups when adjusted for the time spent in the study. 

The effects of omeprazole 40 mg/day and esomeprazole 40 mg/day for 5 days on intragastric acidity have been compared in an open, crossover study in 130 patients with symptoms of gastro-esophageal reflux (20). Esomeprazole provided more effective acid control than twice the standard dose of omeprazole. Adverse effects were similar with the two drugs, and the most commonly reported were headache, nausea, and abdominal pain. 

Esomeprazole provided more effective acid control than omeprazole. Both dosages of esomeprazole were well tolerated, and the profile and incidence of adverse events were similar to that observed with omeprazole. The most common were abdominal pain, nausea, diarrhea, respiratory infection, and headache. 

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