Eslicarbazepine acetate

The results of two single-blind studies of eslicarbazepine acetate and oxcarbazepine after single and repeated administration in healthy volunteers have been reported (see above imder Eslicarbazepine). 

Almeida L, Falcao A, Maia J, Mazur D, Gellert M, Soares-da-Silva P. Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects. J Clin Pharmacol 2005 45(9) 1062-6. 

Almeida L, Nunes T, Sicard E, Rocha JF, Falcao A, Brunet JS, Lefebvre M, Soares-da-Silva P. Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects. Acta Neurol Scand 2010 121(4) 257-64. 

Eiger C, Halasz P, Maia J, Almeida L, Soares-da-Silva P. Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures a randomized, double-blind, placebo-controlled, parallel-group phase III study. Epilepsia 2009 50(3) 454-63. 

Ben-Menachem E, Gabbai AA, Hufnagel A, Maia J, Almeida L, Soar-esda-Silva P. Eslicarbazepine acetate as adjunctive therapy in adult patients with... 

Milovan D, Almeida L, Romach MK, Nunes T, Rocha JF, Sokowloska M, Sellers EM, Soares-da-Silva P. Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers. Epilepsy Behav 2010 18(4) 366-73. 

Vaz-da-Silva M, Almeida L, Falcao A, Soares E, Maia J, Nunes T, Soares-da-Silva P. Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study. Clin Ther 2010 32(1) 179-92. 

Observational studies So-called third generation antiepileptic medications include retigabine, lacosamide, and esli-carbazepine. All three AEDs have linear pharmacokinetics and rapid absorption. The most common adverse effects observed with lacosamide versus placebo were dizziness, headache, diplopia, and nausea with retigabine, they were dizziness, somnolence, and fatigue and with eslicarbazepine acetate, dizziness and somnolence were reported [26 ]. 

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