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Erythropoietin therapeutic applications

Biomedical research continues to broaden our understanding of the molecular mechanisms underlining both health and disease. Research undertaken since the 1950s has pinpointed a host of proteins produced naturally in the body that have obvious therapeutic applications. Examples include the interferons and interleukins (which regulate the immune response), growth factors, such as erythropoietin (EPO which stimulates red blood cell production), and neurotrophic factors (which regulate the development and maintenance of neural tissue). [Pg.3]

Fenn JB, Mann M, Meng CK Electrospray ionization for mass spectrometry of large biomolecules. Science (1989) 246 64-71. Patrick JS, Lagu AL Review applications of capillary electrophoresis to the analysis of biotechnology-derived therapeutic proteins. Electrophoresis (2001) 22 4179-4196. Sowell J, Salon J, Strekowski L, et al Covalent and noncovalent labeling schemes for near-infrared dyes in capillary electrophoresis protein applications. Methods Mol. Biol. (2004) 276 39-75. Moini M Capillary electrophoresis mass spectrometry and its application to the analysis ofbiological mixtures. Anal. Bio-anal. Chem. (2002) 373 466 180. Nemunaitis J, Holmlund JT, Kraynak M, et al. Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-a, in patients with advanced cancer./. Clin. Oncol. (1999) 17 3586-3595. De Frutos M, Cifuentes A, Diez-Masa JC Differences in capillary electrophoresis profiles of urinary and recombinant erythropoietin. Electrophoresis (2003) 24 678-680. [Pg.177]

An interesting application of polycations is the encapsulation of cells, which can be considered as a form of a drug if used therapeutically, e.g. as implants or due to the substances they secrete, e.g. erythropoietin (EPO) or insulin. [Pg.311]


See other pages where Erythropoietin therapeutic applications is mentioned: [Pg.274]    [Pg.187]    [Pg.709]    [Pg.636]    [Pg.94]    [Pg.269]    [Pg.10]    [Pg.46]    [Pg.320]    [Pg.9]    [Pg.260]    [Pg.68]    [Pg.76]    [Pg.239]    [Pg.92]    [Pg.945]    [Pg.1001]    [Pg.39]    [Pg.92]    [Pg.205]    [Pg.654]    [Pg.456]   
See also in sourсe #XX -- [ Pg.266 ]




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