Erythromycin, radioactive

A widely used method to produce multiple-unit dosage forms has been the production of sachets that contain film-coated granules. More common is the use of capsules in which enteric-coated particles are filled. A study that used radioactive tracers revealed that enteric-coated erythromycin pellets in capsules were superior to enteric-coated tablets with respect to faster action of the drug caused by a shorter passage time of the coated granules in the stomach [49-51],... 

Figure 9b. Concentration of total radioactivity in tissue after oral administration (50 mg/kg) of C-erythromycin to lobsters Homarus americanus) (n = 6).

Fig. 4. Whole-body autoradiograms showing the distribution of radioactivity 5 min after intravenous administration of C-clarithromycin (TE-031) and C-erythromycin (EM) (5 mg/kg) to rats. (From Kohno et al. [60], Fig, 2, p. 754.)...

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