Erythromycin mercaptosuccinate

C3H5CIO 79-03-8) see Betamethasone butyrate propionate Betamethasone dipropionate Docarpamine Erythromycin estolate Erythromycin monopropionate mercaptosuccinate Flavoxate Fluticasone propionate Naproxen Prednicarbate Quinethazone 2-propionyloxybenzoic acid (Ci H,o04 6328-44-5) see Flavoxate... 

C4H5O4S 70-49-5) see Erythromycin monopropionate mercaptosuccinate Sodium aurothiomalate thionyl bromide... 

Ester derivatives of erythromycin, shown in Table 4, were synthesized soon after its discovery (124—126). They are readily prepared by acylation of the 2-hydroxyl group the neighboring 3r-dimethylamino group directs acylation to this site. Commonly used esters of erythromycin are propionate, acetate, ethyl succinate, and ethyl carbonate (30). 2r-Esters do not bind bacterial ribosomes, however, and consequently must be hydrolyzed back to the parent to exert antibacterial activity (127). Ester derivatives are still being prepared (128,129). 2,-0-Acetylerythromycin stearate, also known as erythromycin acistrate, is an example undergoing clinical trial (11,130,131). Two salts of 2,-0-propionyl-erythromycin, N-acetylcysteinate (erythromycin stinoprate) and mercaptosuccinate, were prepared to combine antibiotic and mucolytic properties in a single agent (132—134). 

Combinations of a 2 -ester and a lipophilic acid-addition salt have also been extensively employed. Erythromycin estolate (2 -propionate, lauryl sulphate salt) has been widely used due to its better oral absorption than other forms of erythromycin [62, 67, 68]. Similar results have been found with erythromycin acistrate (2 -acetate, stearate salt) [69, 70], which is reported to be less hepatotoxic in animals than other forms of erythromycin [71], Two salts of 2 -propionylerythromycin,A-acetyIcysteinate (erythromycin stinoprate) and mercaptosuccinate, are being investigated as combinations of an antimicrobial and mucolytic agent [72-74],... 

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