Erythroblastosis foetalis

The underlying cause of human bilirubin encephalopathy is almost always erythroblastosis foetalis or a deficiency of the fiver bilirubin conjugating enzyme... 

PHYSIOLOGICAL ACTIVITY General comments Hallucinogenic activity Haemostatic action Radioprotective activity Control of erythroblastosis foetalis... 

The Rh factor was first recognised in 1940 and shortly afterwards its role in the etiology of erythroblastosis foetalis was described. Later the Rh positive red cells from the foetus were incriminated as bearing the antigen responsible for antibody formation in the mother in erythroblastosis. The proof of the transplacental passage of foetal erythrocytes eventually came with the detection of the foetal cells in the maternal circulatory system. 

L22. Lie-Injo, L. E., and Lie Hong, G., Abnormal haemoglobin production as a probable cause of erythroblastosis and hydrops foetalis in uniovular twins. Acta Haematol. 25, 192-199 (1961). 

---