Erspamer

Montecucchi PC, de Castiglione R, Piani S, Gozzini L, Erspamer V. Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei. Int J Peptide Protein Res 1981 17 275-283. 

Erspamer Y, Melchiorri P, Falconieri-Erspamer G, et al. Deltorphins a family of naturally occurring peptides with high affinity and selectivity for opioid binding sites. Proc Natl Acad Sci USA 1989 86 5188-5192. 

Cane toad biogenic amines fall into three classes, the catecholamines, the indolylalkylamines and an alkaloid. The catecholamine adrenaline is a significant portion (6-11%) of the skin secretions (Erspamer 1994 Gregerman 1952). Parotoid and... 

More than twenty indole derivatives have been identified from bufonid skin extracts. The indolylalkylamines bufotenidine, bufotenine, de-hydrobufotenine, bufo-tionine and serotonin (5-hydroxytryptamine) (Fig. 39.2b) have been identified in skin secretions of Bufo marinus, while the latter four have been detected in parotoid gland secretions (Erspamer 1994 Maciel, Schwartz, Pires Jr, Sebben, Castro, Sousa, Fontes and Schwartz 2003). The concentration of serotonin in the dried secretion of B. marinus was found to equate to approximately 0.1% of the total composition and primarily acts as a vasoconstrictor (Gregerman 1952 Toledo and Jared 1995). 

Erspamer, V. (1994) Bioactive secretions of the amphibian integument. In H. Heatwole and... 

Spande, T. E., Edeards, M. W., Pannell, L. K., Daly, J. W., Erspamer, V. and Melchiorri, P. 1988. Pseudophrynamine A An unusual prenylated pyrrol[2,3,-(3]indole ester from an Australian frog, Pseudophryne coriacea (Myobatrachidae). Journal of Organic Chemistry, 53 1222-1226. 

Severini C, Improta G, Falconieri-Erspamer G, Salvador S, Erspamer V (2002) The tachykinin peptide family. Pharmacol Rev 54 285-322... 

Erspamer, V., Melchiorri, P., Falconieri-Erspamer, G., Negri, L., Corsi, R., Severin , C., Barra, D., Simmaco, M., Kreil, G. Deltorphins a family of naturally occurring peptides with high affinity and selectivity for Sopioid binding sites, Proc. Natl. Acad. Sci. USA 1989, 86, 5188-5192. 

Patrizia Campolongo (117), Department of Physiology and Pharmacology, Vittorio Erspamer , Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy... 

Klofta, T.J., Erspamer, J.P., and Berg, R.W., Anti-Viral, Anhydrous, and Mild Skin Lotions for Application to Tissue Paper Products, U.S. Patent 5,830,487, November 3, 1998. 

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