Pseudophryne coriacea

Spande, T. E., Edeards, M. W., Pannell, L. K., Daly, J. W., Erspamer, V. and Melchiorri, P. 1988. Pseudophrynamine A An unusual prenylated pyrrol[2,3,-(3]indole ester from an Australian frog, Pseudophryne coriacea (Myobatrachidae). Journal of Organic Chemistry, 53 1222-1226. 

A major class of amphibian alkaloids was recently discovered in frogs of the myobatrachid genus Pseudophryne (86,119). These represent the unidentified indolic compounds first noted by Erspamer and co-workers in 1976 (169). Isolation of two of these indole alkaloids from partially purified extracts of Pseudophryne coriacea allowed structure elucidation of pseudophrynaminol (XIV) and pseudophrynamine A (XV) by nuclear magnetic resonance spectral analysis (119). Methoxide cleavage of pseudophrynamine A yielded pseudophrynaminol and a methyl ester... 

Other comparable examples are known. The main alkaloid in a Nova Scotia collection of Flustra foliacea, dihydroflustramine C, is related to pseudophrynaminol from the skin of the myobatrachid burrowing frog Pseudophryne coriacea. Both classes of alkaloids are based on the 3a-prenyl pyrrolo[2,3- >]indole skeleton (31). 

Pseudophryne coriacea Castor fiberei Moschus moschiferus Solenopsis invicta Dontomachus hastatus Ontomachus brunneus Reticuliterms flavipes... 

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