Ergotamine hypertension with

Pregnancy (ergotamine s powerful uterine stimulant actions may cause fetal harm) hypersensitivity to ergot alkaloids peripheral vascular disease (eg, thromboangiitis obliterans, leutic arteritis, severe arteriosclerosis, thrombophlebitis, Raynaud s disease) hepatic or renal impairment severe pruritus coronary artery disease hypertension sepsis. The use of potent CYP3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is contraindicated. 

IV use ischemic heart disease silent ischemia, Prinzmetal s angina, uncontrolled hypertension, concurrent ergotamine-containing preparations, hemiplegic or basilar migraine Caution with liver and kidney problems... 

A sudden and temporary hypertension (a-effect) and subsequent hypotension (P-effect) are observed from the intravenous injection of epinephrine. However, if ergotamine or ergotoxine was injected previously, the a-effect was not observed, and only the -effect (hypotensive activity) occurred. This is known as the a-blocking effect of the ergot alkaloids. Such an effect is also shown by yohimbine, described previously (Section 2.11). On the other hand, through treatment with ergometrine, an immediate and strong uterine... 

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