Ergot derivatives causing

Contraindications Concomitant use of ergot derivatives (causes peripheral ischemia of extremities and vasospasm), flecainide, midazolam, pimozide, propafenone (increases the risk of serious cardiac arrhythmias), or triazolam (increases sedation or respiratory depression) hypersensitivity to lopinavir or ritonavir... 

Efavirenz (Sustiva) [Antiretroviral/NNRTI] Uses Hiv infxns Action Antiretroviral nonnucleoside RTI Dose Adults. 600 mg/d PO qhs Feds. See package insert avoid high-fat meals Caution [D, ] CDC recommends HIV-infected mothers not breast-feed Contra Component sensitivity Disp Caps SE Somnolence, vivid dreams, dizziness, rash, N/V/D Interactions T Effects W/ ritonavir T effects OF CNS depressants, ergot derivatives, midazolam, ritonavir, simvastatin, triazolam, warfarin X effects W/ carbamazepine, phenobarbital, rifabutin, rifampin, saquinavir, St. John s wort i effects OF amprenavir, carbamazepine, clarithromycin, indinavir, phenobarbital, saquinavir, warfarin may alter effectiveness OF OCPs EMS Concurrent EtOH usage can t CNS d ression OD May cause muscle contractions and adverse CNS effects activated charcoal may be effective... 

Ergot derivatives—eg, ergotamine, dihydroergotamine—cause reversible --receptor blockade. However, most of the clinically significant effects of these drugs are the result of other actions eg, ergotamine probably acts at serotonin receptors in the treatment of migraine (Chapter 16 ... 

Dexfenfluramine caused serotonin release and inhibited reuptake at moderately low concentrations. It also stimulated 5-HT receptors at relatively low concentrations. Metergoline, an ergot derivative with high affinity for 5-HT receptors, completely blocked the anorexiant effect of dexfenfluramine, further suggesting a serotonergic action. 

BETA-BLOCKERS ERGOT DERIVATIVES Three reported cases of arterial vasoconstriction and one of T BP occurred when ergotamine or methysergide was added to propanolol or oxprenolol Ergotamine can cause peripheral vasospasm, and absence of beta-adrenergic activity can t the risk of vasoconstriction Ergot derivatives and beta-blockers are often co-administered without trouble however, monitor BP at least weekly until stable (watch for t BP) and warn patients to stop the ergot derivative and seek medical attention if they develop cold, painful feet... 

Like other ergot derivatives, LSD causes contractions of the ulerus. Pregnant women should not take it. 

Most of the dopamine receptor agonists in current use are ergot derivatives, and these are known to cause serosal fibroinflammatory syndromes. 

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