Ergolines lisuride

Figure 13.7. Chemical structure of some ergolines that have been or are currently used in the treatment of Parkinsonism. The outline structure of dopamine is also given to show why these drugs act as dopamine receptor agonists. The extended side chains in lisuride may also account for the action of the drug on 5-HT (particularly 5-HT2) receptors. The hallucinogenic effects of lisuride may be attributed to its action on central 5-HT2 receptors.

In contrast to the tricyclic partial ergolines, the tetracyclic ergolines such as d-LSD (pK =8.7), lisuride (pKj=9.1) or pergolide (pKj=8.7) bind with high affinity to 5-HT1A receptors but they lack selectivity. 

Terguride (55) and lisuride (56) are structurally very similar ergoline derivatives with urea side chain (Figure 18). Lisuride is selective D2-agonist and together... 

The important effect of ergolines on humoral immune mechanisms concerns the induction of lymphokine prodnction mediated by both T lymphocytes and NK cells. The liberation of IFN-y release following mitogenic stimulation is significantly elevated after treatment of patients by lisurid (Baier and Poehlau, 1994 Poehlau et al, 1994). 

Structurally closely related to LSD, Lisuride (226) is a compound having a 3,3-dimethylureido substituent, at die 9-position of the ergoline skeleton, and was first prepared in 1960 as a dopamine Dj-receptor agonist (98). Lisuride, as its acid maleate, is commercially available under Ae names of Cuvalit, Dopergin, Eunal, or Lysenyl, and is used clinically as an antimigraine and also as a prolactin inhibitor. The pharmacological activi and toxicity of lisuride were... 

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