1.2- Epoxy-7-octene

Similarly, addition of diethyl fluoroiodomethylphosphonate to l,2-epoxy-5-hexene and 1,2-epoxy-7-octene on heating at 75°C in the presence of Pd(PPh3)4 gives the corresponding diethyl l-fluoro-3-iodo-6,7-epoxyheptylphosphonate and diethyl l-fluoro-3-iodo-8,9-epoxynonylphospho-nate in 69% and 65% yields, respectively. ... 

To a solution of 1,2-epoxy-7-octene (0.50 mg, 4.0 mmol) and methylbis(trimethyl-silyloxy)silane (0.90 g, 4.0 mmol) in xylene (5.5 mL) is added a solution of the carbene-platinum complex in xylene (90 mL, 0.20 pmol, prepared by dissolving 28 mg of the platinum catalyst in 20 mL of xylene) at 72 °C. The reaction mixture is heated at 72 °C for 210 min (the reaction is monitored by GC) and then cooled. The resulting colorless solution is filtered through a short pad of charcoal, and the solvent is removed under vacuum. The crude product was purified by chromatography on silica gel (petroleum ether-5% Et3N) to give the title compound in 90% yield. ... 

FLUORINECOMPOUNDS,ORGANIC - PERFLUOROEPOXIDES] (Vol 11) Perfluoro-7,8-epoxy-l-octene [72264-78-9]... 

A recent oommtiruo tion by Gritter and Wallace discloses initiation of a study of the free-radical chemistry of epoxides Under the influence of U t-butoxy radicals, formed by thermal decomposition of di-lerf-butyl peroxide, propylene oxide is believed to yield an epoxy radical as shown in Eq. (3). The latter undergoes Isomerization to CHsCOCH - and further reaction with unreaoted propylene oxide or other available substrates, such as 1-octene, toluene, oyolohexene, and ethanol,fl7a as shown in Eq. (3). 

Several Himple alkyl- and phenyl-substituted ethylene oxides have wen prepared in good yield by this procedure (Eq. 296). These include l-heptene oxide, 41 1-octene oxide,161 1-hexadeoone oxide, 46 cyclo-licxylothylene oxide,240 1,2-epoxy-4-phenylbutane,1 40 and 1,2-epoxy-J -pi icnylpr opane. 40>1BSo- . ws ... 

The electrochemical epoxidation of 30a (R = CH2S02Ph) proceeds smoothly to give 6,7-epoxy-3,7-dimethyl-l-(phenylsulfonyl)-2-octene 31 a (R = CH2S02Ph) in... 

The existence of a cytosolic epoxide hydrolase was first indicated by its ability to hydrolyze analogs of insect juvenile hormone not readily hydrolyzed by microsomal epoxide hydrolase. Subsequent studies demonstrated a unique cytosolic enzyme catalytically and structurally distinct from the microsomal enzyme. It appears probable that the cytosolic enzyme is peroxisomal in origin. Both enzymes are broadly nonspecific and have many substrates in common. It is clear, however, that many substrates hydrolyzed well by cytosolic epoxide hydrolase are hydrolyzed poorly by microsomal epoxide hydrolase and vice versa. For example, l-(4 -ethylphenoxy)-3,7-dimethy I -6,7-epoxy-//7//i,v-2-octene, a substituted geranyl epoxide insect juvenile hormone mimic, is hydrolyzed 10 times more rapidly by the cytosolic enzyme than by the microsomal one. In any series, such as the substituted styrene oxides, the trans configuration is hydrolyzed more rapidly by the cytosolic epoxide hydrolase than is the cis isomer. At the same time, it should remembered that in this and other series,... 

In analogy with primary allylic alcohols, a secondary allylic alcohol bearing a bulky E-substituent (R ) is a good substrate for kinetic resolution. For example, the k ei for (E)-l-cyclohexyl-2-buten-l-ol is 104 and that for l-cyclohexyl-4,4-dimethyl-2-penten-l-olis 300 [59]. Best substrates are those in which the -sub-stituent is trimethylsilyl, iodo, or trimethylstannyl. The relative rate constant for (E)-l-trimethylsilyl-l-octen-3-ol is 700 and, at 50% conversion,both the imre-acted alcohol and the anti-epoxy alcohol have more than 99% ee (Scheme 12)... 

CH3CH2CH2CH=CHCH2OH2CH3 RC0 11 CH3CH2CH2CH—CHCH2CH2CH3 4-Octene 4,5-Epoxy octane... 

Henequen microfibres were treated with two different epoxides (l,2-epoxy-5-hexene and l,2-epoxy-5-octene), in order to append insaturations at their surface, which were then used as potential comonomer units when acrylic acid was polymerized in their presence [73]. The ensuing materials displayed a substantial increase in water absorption given the well-known hydrophilic character of acrylic acid. 

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