Epoxide hydrolases styrene derivatives

Furstoss et al. have reported their studies on the use of an epoxide hydrolase with four styrene oxide derivatives (Figure 5.26) [39]. The (R)-diol (43) was obtained in 91% ee at 100% conversion from racemic (42), demonstrating an enantioconvergent... 

J.-H. Woo, E.Y. j e, Enantioselective hydrolysis of racemic styrene oxide and its substituted derivatives using newly-isolated Sphingopyxis sp. exhibiting a novel epoxide hydrolase activity, Biotechnol. Lett. 36 (2014) 357-362. 

Monteide, M.I., Lombard, M., Archelas, A., Cronin, A., Arand, M. and Furstoss, R. (2004) Enzymatic transformations. Part 58 Enantioconvergent biohydrolysis of styrene oxide derivatives catalysed by the Solanum tuberosum epoxide hydrolase. Tetrahedron Asymmetry, 15,2801-2805. 

Botes, A.L., Letter, J., Labuschagne, M. and Mitra, R.K. (2005) Methods for the preparation of optically active epoxides and vicinal diols from styrene epoxides using enantiose-lective epoxide hydrolases derived from yeasts. WO Patent 100569 A2 (CSIR, October 27, 2005). 

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