Epoprostenol

Sample preparation Pack a polypropylene column with 1 g Hi-Flosil (80/100) C18 material (Apphed Science) in an MeCN slurry, add 5 mL 10% dimethyldichlorosilane in toluene, wash with 15 ml. toluene, wash with 15 mL MeCN. Just prior to use, equihbrate with 15 mL 2 mM sodium borate adjusted to pH 10 with NaOH. Mix 1 mL whole blood with 10 mg/mL sodium carbonate solution, keep on ice, centrifiige at 2000 g at 4° for 10 min, add a 500 lL aUquot to the SPE column, wash with two 3 mL portions of 2 mM pH 10 sodium borate, elute with three 3 mL portions of MeCN 2 mM pH 10 sodium borate 40 60. Collect the eluate in a container containing 200 p.L 200 mM NaOH. Evaporate the eluate to dryness under reduced pressure at 40°, reconstitute the residue with 1 mL 2 mM pH 9.1 sodium borate, inject a 100 ixL ahquot. [Pg.224]

Mobile phase Gradient. MeCN 2 mM pH 9.1 sodium borate from 12 88 to 27 73 over 7 min. [Pg.224]

Skrinska, V. Lucas, P.V. Isolation of prostacycUn from whole blood. Prostaglandins, 1981,22, 365-375. [Pg.224]

Cross Index of Drugs Milenperone Epoprostenol Calcitriol... [Pg.1309]

Prostaglandin EJ (Prostin VR) Epoprostenol (Rolan) Fenoldopam (Corlopam) Hydralazine... [Pg.41]

Epoprostenol is the natural occurring prostacyclin which is formed in vascular endothelial cells. It increases cyclic AMP in the thrombocyte and is a strong platelet aggregation inhibitor. It is used to prevent thrombotic complications during hemodialysis when heparin is contraindicated. As its duration of action is no longer than 30 minutes it has to be given as an intravenous infusion. [Pg.373]

See also in sourсe #XX -- [ Pg.10 ]

See also in sourсe #XX -- [ Pg.159 ]

See also in sourсe #XX -- [ Pg.10 ]

See also in sourсe #XX -- [ Pg.149 ]

See also in sourсe #XX -- [ Pg.367 ]

See also in sourсe #XX -- [ Pg.149 ]

See also in sourсe #XX -- [ Pg.56 , Pg.56 ]

See also in sourсe #XX -- [ Pg.757 ]

See also in sourсe #XX -- [ Pg.281 , Pg.583 ]

See also in sourсe #XX -- [ Pg.338 , Pg.736 ]

See also in sourсe #XX -- [ Pg.302 ]

See also in sourсe #XX -- [ Pg.109 ]

See also in sourсe #XX -- [ Pg.240 ]

See also in sourсe #XX -- [ Pg.177 ]

See also in sourсe #XX -- [ Pg.866 ]

See also in sourсe #XX -- [ Pg.149 ]

See also in sourсe #XX -- [ Pg.82 ]

See also in sourсe #XX -- [ Pg.318 ]

See also in sourсe #XX -- [ Pg.792 , Pg.793 ]

See also in sourсe #XX -- [ Pg.4 , Pg.71 , Pg.165 ]

See also in sourсe #XX -- [ Pg.357 ]

See also in sourсe #XX -- [ Pg.216 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...