Epilepsy histamine

Drugs that act on the H3 receptor are being developed for the treatment of obesity, sleep disturbances, epilepsy and cognitive disorders. The ability of histamine to promote arousal, suppress appetite, elevate seizure threshold and stimulate cognitive processes implies that compounds able to enhance the release of neuronal histamine should mimic these effects. Several H3 antagonists currently in development demonstrate such activity and show promise as effective and novel therapeutic agents [40, 84-86]. Because H3 agonists suppress the release of... 

Histamine Hr Human cDNA Allergy inflammation, asthma, chronic sinusitis, rhinitis, epilepsy migraine, motion sickness, pain, cancer Smooth muscle contraction, increase in vascular permeability stimulation of hormone release (adrenal medulla), increase in neuronal firing... 

In conclusion, from the findings of various basic researches, histamine H3 antagonists may be useful for the therapies of Altzheimer s disease, narcolepsy, schizophrenia, and depression in addition to dementia and epilepsy. 

Finally, histaminergic neuron activity seems to protect against convulsions (Zhang et al. 2003 Lintunen et al. 2005), epilepsy is a potential indication for H3 receptor antagonists (Harada et al. 2004 Stark et al. 2004), and their anticonvulsive effect has been partly explained by an increase in histamine release (Yokoyama et al. 1994 Harada et al. 2004). 

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