Epilepsy electrophysiology

Cellular mechanisms underlying hyperexcitability have been analyzed by electrophysiological studies of hippocampal slices isolated from animals with epilepsy 632... 

The International Classification of Epileptic Seizures (Table 52-1) classifies epilepsy on the basis of clinical description and electrophysiologic findings. 

Racine RJ, Steingart M, McIntyre DC. 1999. Development of kindling prone and kindling resistant rats selective breeding and electrophysiological studies. Epilepsy Res... 

The International Classification of Epileptic Seizures (Table 52-1) classifies epilepsy on the basis of clinical description and electrophysiologic findings. Partial (focal) seizures begin in one hemisphere of the brain and, unless they become secondarily generalized, result in an asymmetric seizure. Partial seizures manifest as alterations in motor functions, sensory or somatosensory symptoms, or automatisms. If there is no loss of consciousness, the seizures are called simple partial. If there is loss of consciousness, they are termed complex partial, and the patients may have automatisms, memory loss, or aberrations of behavior. 

Hardus P, Verduin WM, Berendschot TT, Kamermans M, Postma G, Stilma JS, van Veelen CW. The value of electrophysiology results in patients with epilepsy and vigabatrin associated visual field loss. Acta Ophthalmol Scand 2001 79(2) 169-74. 

Autosomal dominant nocturnal frontal-lobe epilepsy (ADNFLE) is a form of partial epilepsy which is characterized by frontal-lobe motor seizures occurring during sleep (Philips et al., 1998). This disorder has been linked to a mutation in the channel-lining domain (M2) of the a 4 nicotinic receptor subunit with use-dependent potentiation of the electrophysiological response to nicotinic agonists (Lena and Changeux, 1998). If the symptoms of ADNFLE are secondary to overactivity of this receptor or unusual potentiation, then nicotinic antagonists such as mecamylamine may be helpful. 

Johnston, D. T.H. Brown. 1984. Mechanism of neuronal burst generation. In Electrophysiology of Epilepsy. Academic Press, New York, pp. 277-301. 

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