Epidemics overview

Abstract This review provides an overview of the development of viral protease inhibitors as antiviral drugs. We concentrate on HlV-1 protease inhibitors, as these have made the most significant advances in the recent past. Thus, we discuss the biochemistry of HlV-1 protease, inhibitor development, clinical use of inhibitors, and evolution of resistance. Since many different viruses encode essential proteases, it is possible to envision the development of a potent protease inhibitor for other viruses if the processing site sequence and the catalytic mechanism are known. At this time, interest in developing inhibitors is Umited to viruses that cause chronic disease, viruses that have the potential to cause large-scale epidemics, or viruses that are sufQciently ubiquitous that treating an acute infection would be... 

A high proportion of human and animal diseases are caused by viruses, from the common cold to poliomyelitis, rabies, hepatihs, and many others. Table 9.1 provides an overview of viruses causing diseases in humans. In the last two decades of the twentieth century, the emergence of the AIDS epidemic focused attention on the need to develop... 

Cannon SB, Veazey JM Jr, Jackson RS, et al Epidemic kepone poisoning in chemical workers. Am J Epidemiol 107 529-537,1978 Chambers HW Organophosphorus compounds an overview, in Organophosphates Chemistry, Fate and Effects. Edited by Chambers JE, Levi PE. San Diego, CA, Academic Press, 1992, pp 3-17... 

Glasgow proper was around 195,000 at this time, these data suggest that 1 out of every 32 of the city s residents had cholera, and that 1 out of every 68 residents died from the disease. For an overview of this and other cholera epidemics in Glasgow, see table 8.1. 

---