Ephrin Ligands and Eph Kinases

Eph receptor tyrosine kinases play a crucial role in intercellular processes such as angiogenesis, neurogenesis, and carcinogenesis. Based on their affinity for ephrin ligands, the Eph kinases are divided into two subfamilies, EphA and EphB, which bind to ephrinA and ephrinB, respectively [60]. 

In the resulting score plot, the first PC discriminated between the ephrins and the Eph kinases, which is in agreement with the complementary nature of interactions between these proteins. A separate classification of the kinases and ligands clearly showed two clusters corresponding to the A and B subfamilies. Kinases with a unique biological interaction profile showed up as outliers in the score plot. 

Subsequently, the authors analyzed the structural basis of the eph-Eph kinase interaction. The differential plots for the cluster of Eph kinases and the cluster of ephrins, highlighted the complementary binding regions, i.e. areas of favorable interaction between kinase and ligand. Additionally, the differences between the 

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Myshkin, E. and Wang, B. Chemometrical classification of ephrin ligands and eph kinases using GRID/CPCAapproach./. Chem. Inf. Comput. Sci. 2003, 43, 1004-1010. 

E. Myshkin, B. Wang, Chemometrical classification of ephrin ligands and Eph kinases using GRID/CPCA approach,... 

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