Sibutramine Ephedrine

Persky, A. M., C. Ng, M. H. Song, M. E. Lancaster, D. E. Balderson, M. A. Paulik, et al. (2004). Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers. Int J Clin Pharmacol Ther 42(8) 442-8. 

Clinically important, potentially hazardous interactions with amitriptyline, amoxapine, amphetamines, bupropion, citalopram, clomipramine, cyproheptadine, desipramine, dextroamphetamine, dextromethorphan, diethylpropion, dopamine, doxepin, entacapone, ephedra, ephedrine, epinephrine, fluoxetine, fluvoxamine, ginseng, imipramine, levodopa, mazindol, meperidine, methamphetamine, nefazodone, nortriptyline, paroxetine, phendimetrazine, phentermine, phenylephrine, pizotifen, propoxyphene, protriptyline, pseudoephedrine, rizatriptan, sertraline, sibutramine, sumatriptan, sympathomimetics, tramadol, tricyclic antidepressants, trimipramine, tryptophan, venlafaxine, zolmitriptan... 

The UK manufacturers say that the concurrent use of sibutramine and other centrally acting appetite suppressants is contraindicated. No work appears to have been done to see what happens if sibutramine is given with decongestants, cough, cold and allergy medications, but the manufacturers advise caution because of the risk of raised blood pressure or heart rate. The manufacturers in the UK and US both list ephedrine and pseu-doephedrine, while in the UK sylometazoline is also specifically named. ... 

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