Ephedrine nasal drops

Bechgaard E, Bindseil E, Bagger M, Nielsen HW. Reversibility and clinical relevance of morphological changes after nasal application of ephedrine nasal drops 1%. Int Pharm 1997 152 67-73. 

The Joint Committee" of the Pharmaceutical Society and the Society for Analytical Chemistry recommended a gas chromatographic method for the determination of ephedrine in tablets, elixir and nasal drops, using phenmetrazine as an internal standard. Ephedrine was extracted... 

The administration of ephedrine may be given orally or topically as nasal drops or... 

Nasal Drops of Ephedrine, B.P.C, Contain 0 91 per cent w/v of ephedrine hydrochloride. The determination of ephedrine follows the standard distillation method given above using 20 ml of sample. 

Ephedrine hydrochloride nasal drops 0.5% w/v. Adult dose 1-2 drops into each nostril 3 to 4 times daily. 

Nasal formulations of modern sympathicomimet-ics like oxymetazoline and xylometazoline are effective. Rebound nasal congestion after withdrawal of sympathicomimetic-containing nose sprays or drops is a common phenomenon and patients should be advised to use these medicaments no longer than 3-5 days. Older per oral drugs like ephedrine and pseudo-ephedrine have no place in the therapy of rhinitis due to the risk of serious adverse reactions which are not in proportion to the indication. 

Ephedrine can be administered by almost any route. Most frequently, it is given orally. It is also injected subcutaneously, intramuscularly, or intravenously. For local action, as in the eye or on the nasal mucosa, ephedrine solutions are applied directly by drops, on a tampon, or as a spray. 

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