Enzymology, clinical use

A unit of enzyme catalytic activity equal to the conversion of one mole of substrate per second in a specified assay system. The katal (kat) is more commonly used in clinical enzymology. One unit of enzyme activity (i.e., one micromole per minute) corresponds to 16.67 nkat. 

Bioluminescence is a unique type of chemiluminescence found in biological systems these reactions can be classified as either pyridine- or adenine-nucleotide linked systems or enzyme-substrate systems. In clinical enzymology, the most commonly used system is the firefly luciferin-luciferase system for the measurement of ATP ... 

R. Rej and R. Vanderlinde, Use of Purified Enzyme Reference Materials in Enzyme Activity Measurements, in Proc. Second International Symposium on Clinical Enzymology (eds. N. W. Tietz and A. Weinstock), American Association for Clinical Chemistry, Washington, DC, 1976, p. 249. 

It should be noted that many polar substances with poor solubilities in the usual solvents can be dissolved in water or in D2O. Examples of the potential use of aqueous solutions in pharmaceutical research are to be found in the discussions of aqueous solutions (thap. 3), enzymology (Chap. 15), hydrogen-deuterium exchange (Chap. 11), nucleic acids (Chap. 12), carbohydrates (Chap. 6), amino acids (Chap. 9), amines (Chap. 8), clinical chemistry (Chap. 18), and inorganic ions (Chap. 19). 

The first volume of a new series entitled Applied Biochemistry and Bioengineering deals with the principles of immobilized enzymes, which, among other topics, are also discussed in one of the latest volumes of Methods in Enzymology . Recent reviews have covered the uses of immobilized enzymes and immobilized microbial cells in industry, the design of immobilized-enzyme flow reactors, the properties of immobilized enzymes, the reactions used to immobilize enzymes, and the uses of immobilized enzymes in clinical diagnosis, detoxification, and therapy, etc. and of immobilized microbial cells. 

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