Enzyme recruitment

Fall RR, JI Brown, TL Schaeffer (1979) Enzyme recruitment allows the biodegradation of recalcitrant branched hydrocarbons by Pseudomonas citronellolis. Appl Environ Microbiol 38 715-722. 

Lehrbach.P. R.,Zeyer,J., Reineke, W., Knackmuss, H-J. Timmis, K. N. (1984). Enzyme recruitment in vitro-, use of cloned genes to extend the range of haloaromatics degraded by Pseudomonas sp. strain B13- Journal of Bacteriology, 158, 1025-32. 

S. Briisselbach, T. Korn, T. Volkel, R. Muller, and R. Kontermann, Enzyme recruitment and tumor cell killing in vitro by a secreted bispecific single-chain diabody, Tumor Targeting 4 115 (1999). 

RA Jensen. Enzyme recruitment in evolution of new function. Annu Rev Microbiol 30 409-425, 1976. 

Let us point out a perhaps even more severe objection. Historical retroevolution is fully compatible with the patchwork type of enzyme recruitment, provided at least two pathways are present and evolving in parallel. The higher the number of pathways, the more patchworky the recruitment can be, even though each individual pathway is retroevolving. 

Copley S. D. (1998) Microbial dehalogenases enzymes recruited to convert xenobiotic substrates. Curr. Op. Chem. Biol 2, 613-617. 

A large part of the HAT activity functions in a gene-specific manner via specific interactions between transcription activators and the HAT complexes. We now know of numerous examples of transcription activators that target HAT activity to specific genes. A HAT enzyme recruited by many activators is p300/CBP, which is found as part of the PCAF complex. Examples of transcription activators that recruit HAT activity are... 

Some populations of herbicide-resistant weeds are resistant as a result of increased herbicide detoxification mechanisms. Where this has occurred, the same detoxification processes are involved as in crops. However, as the major detoxifying enzymes occur in large superfamilies in plants, the enzymes recruited for resistance in weeds are not necessarily the same as those responsible for herbicide detoxification in crops. This means that patterns of resistance in weeds do not necessarily follow the patterns of selectivity in crops and that regulation of the detoxification process may be different. 

Wells, J.A., et al. Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering. Proc. Natl. Acad. Sci. USA 84 5167-5171, 1987. 

In the case of liganded NRs, ligand binding is the first and ciucial molecular event that switches the function of these transcription factors from inactive to active state by inducing a conformational change in the LBD of the receptor (Fig. 1). This specific conformation allows the second step of NR activation that corresponds to the recruitment of coregulatoiy complexes, which contain chromatin-modifying enzymes required for transcription. The transcriptional coactivators are very diverse and have expanded to more than hundred in number. These include the pi 60 family of proteins,... 

Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O (2007) Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. EMBO J 26(2) 412-423... 

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